So concludes a new study published in the current issue of Journal of Allergy and Clinical Immunology in which researchers compared 18 previous trials investigating antihistamine-caused sedation levels in 1,500 people between ages 8 and 81.Most of the studies reviewed used doses that were twice the recommended amount -- 50 milligrams -- of diphenhydramine, the active ingredient in Benadryl and other first-generation "sedating" allergy medications.This is not an indication of a security issue such as a virus or attack.
Seasonal allergic rhinitis: 60 mg orally twice daily or 180 mg once daily.
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Of course, with seasonal allergies, your immune system is reacting to pollen, which isn’t really a threat, and those leaky capillaries are what make you all stuffed up, so taking an antihistamine can block your immune system from overreacting and causing unpleasant inflammation.
First-generation antihistamines such as diphenhydramine (aka Benadryl) have been on the market for decades.
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Please see package insert for additional information and possible updates.Antihistamines are classified into two groups – the first-generation (“sedating”) and second-generation (“non-sedating”).Sedating antihistamines cause sedation as they are highly lipid soluble and readily cross the blood brain barrier.Based on my experience seeing patients, talking to my friends about what they use, and reading some of what’s out there online, I think a lot of people are barking up the wrong tree and suffering needlessly from runny noses, sneezing, congestion, and itchy eyes. Antihistamines block histamine, a chemical involved in inflammatory reactions.Histamine makes tiny blood vessels called capillaries permeable to white blood cells and fluid so that the cells can move out of your blood and into surrounding tissue to fight infection."We're not saying that there's not a difference," says lead researcher Bruce G.