We performed a randomized, open-label, equivalence trial among 2436 school children in western Kenya.Eligible children were randomized to receive either 4 repeated doses or a single dose of albendazole and were followed up during 13 months to assess the incidence of clinical malaria.School children living in the tropics are often concurrently infected with plasmodium and helminth parasites.
Barriers to effective vaccination with oral vaccines in poor populations living in the tropics include nutritional deficiencies (e.g., vitamin A and zinc), chronic diarrhoea, pre-existing mucosal immunity (e.g., intestinal secretory Ig A), the presence of maternal antibodies in breast milk, environmental enteropathy [3, 4], and coinfections with enteric bacterial infections, and protozoal (e.g., Giardia intestinalis) and geohelminth parasites [10].
The geohelminth parasites, Ascaris lumbricoides, Trichuris trichiura, and hookworm have a worldwide distribution and are strongly associated with poverty.
Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Via Interoceanica S/N y Avenida Pampite, Quito, Ecuador Received ; Revised 9 September 2011; Accepted 28 September 2011Academic Editor: Ann-Mari Svennerholm Copyright © 2012 Maritza Vaca et al.
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Secondary outcomes are prevalence of , intensity of species infections and treatment coverage. Among a random subsample of participants, worm burden and proportion of unfertilised eggs will be assessed longitudinally.
A nested process evaluation, using semistructured interviews, focus group discussions and a stakeholder analysis, will investigate the community acceptability, feasibility and scale-up of each delivery system.
This study seeks to answer the question: is it possible to interrupt the transmission of STH, and, if so, what is the most cost-effective treatment strategy and delivery system to achieve this goal?
Methods and analysis Two cluster randomised trials are being implemented in contrasting settings in Kenya.
Our data provide support for the presence of a barrier to oral vaccination among children from the rural tropics that appeared to be independent of concurrent ascariasis.
The use of oral vaccines in children and adults from poor populations, particularly in the tropics, has been associated with reduced efficacy and impaired immune responses.
[6 p.m., Presidio Officers’ Club, 50 Moraga Ave., S. : The session with Stanford University’s Virtual Human Interaction Lab is part of “Coming Clean,” a multimedia art project designed to “amplify” the experience of homelessness through artists’ lenses; visit RWgt to RSVP. F.] Luzia: Cirque Du Solieil opens its six-week South Bay engagement of latest show, a “an acrobatic waking dream of Mexico.” [8 p.m., Big Top, Taylor Street and Highway 87, San Jose] The Story of the Alcatraz Florilegium: Sally Petru, Lyn Dahl and Catherine Watters discuss a 10-year project to restore long neglected plants and gardens on Alcatraz. [8 p.m., Yerba Buena Center for the Arts, 700 Howard St., S. retrospective devoted to influential media artist and feminist art pioneer Lynn Hershman Leeson is celebrated with an opening night party.